ManNAc and Glycoprotein Production Review

This expanded update of the mini-review originally published early in 2013, covers developments in the understanding, role and value of N-acetylmannosamine (ManNAc) to increase sialylation in the production of recombinant therapeutic human glycoproteins and monoclonal antibodies. The report includes references to publications up to late 2014 and includes many more references than the original report. Additional references to the core R&D, includes analytical methods from HPLC-MS through to IEF technologies to measure increased sialylation of glycoproteins.

Click here to read the review.