• World-class manufacturers of bile acids and carbohydrates
  • NZP’s non-GMP kilo lab is complemented by Dextra’s GMP kilo lab
  • Dextra's GMP lab
  • Large scale GMP Freeze drying
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  • Digitally controlled programmable large scale evaporation
  • NMR
  • Freeze Dryers
  • HEPA filtration area behind the scenes
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  • NZP’s non-GMP kilo lab is complimented by Dextra’s GMP kilo lab
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The application of N-acetylmannosamine to the mammalian cell culture production of recombinant human glycoproteins
Selwyn C Yorke
Keywords: N-acetylmannosamine, sialylation, glycoproteins.

This mini-review covers recent developments in the understanding, role and value of N-acetylmannosamine (ManNAc) as a compound that can improve sialylation during the production of recombinant human glycoproteins.


Read the review here: The application of N-acetylmannosamine to the mammalian cell culture production of recombinant human glycoproteins.

Product Catalogue

Pharmaceutical Intermediates and Ingredients

 NZP produces of a range of bulk pharmaceutical intermediates and pharmaceutical ingredients for supply to pharmaceutical and biotechnology companies worldwide.

See Intermediates and Ingredients Products



These bile acids have gained popularity with assistance to solubilise non-polar drugs for delivery in aqueous media by injection.


See Excipient Products

Microbiological Media and Fermentation Ingredients

NZP manufactures several refined bile products that are used as selective inhibitory agents in bacteriological media. These include pure sodium salts of bile acids, which are supplied to biotech and media companies worldwide.

See Media and Fermentation Ingredients Products



NZP’s sister company, Dextra located in Reading, UK, undertakes custom carbohydrate synthesis and offers a catalogue of carbohydrate derivatives for glycobiology and other applications.

See Carbohydrate Products

Dietary Supplements

NZP manufactures a range of dietary supplement ingredients under GMP conditions.

See Dietary Supplement Products

Feed Ingredients

In consultation with the aquaculture industry, NZP has developed Mixed Bile Acids, which is easily incorporated into feeds.
See Feed Ingredient Products

Manufacturing Capabilities

Contract Manufacturing

NZP-Dextra manufactures specialist and niche chemicals, especially bile acids, complex oligosaccharides and other sugar derivatives.

- Multi-step syntheses manufactured to your specification

- Gram to multi-kilogram scale.

- Process optimisation

- Long term manufacturing contracts from kilograms to tonnes per annum.

Manufacturing Specialties

Amongst the Dextra and NZP manufacturing specialties are:

- Bile acid derivatives; for example glycocholic acid

- Sugar derivatives

- Chemical and enzyme synthesis (custom synthesis)

- Natural product extraction and purification from biomass (marine and terrestrial products, small molecule bioactives and polymers)  

- Chemical modification of natural products (GMP)

Manufacturing Technologies

NZP's Manufacturing technologies include:


- Chemical and enzyme synthesis in glass or stainless steel

- Natural product extraction and purification from biomass (marine and terrestrial products)  

- Anhydrous or inert gas blanket chemistry  

- Enzyme and chemical hydrolyses  

- Large scale aqueous and organic solvent extraction

- Ion-exchange purification  

- Distillation

- Ultrafiltration

- Filtration and centrifugation

- Freeze drying - GMP

- Also: spray, vacuum, oven tray drying, crystallisation  

- Milling (grinding)  

- ISO Class 8 clean rooms